Investigating the role of deubiquitylases on the stability of programmed death-ligand 1 and epidermal growth factor receptor in non-small cell lung cancer (360G-Wellcome-203927_Z_16_A)

£0

This project will examine the relationship between two proteins: epidermal growth factor receptor (EGFR) and programmed death-ligand 1 (PD-L1) relevant to non-small cell lung cancer (NSCLC). Mutations in the EGFR drive tumour growth and survival, whilst the presence of PD-L1 at the cell surface limits the effectiveness of an immune response. We will study the relationship between EGFR activity and PD-L1 expression in a model cell system, with the specific aim of identifying intermediary proteins. We will also study each protein individually with the aim of understanding the processes which set the high levels of protein displayed at the cell surface. Both proteins are validated clinical targets, but patients may acquire resistance to the existing drug therapies. Like any population, the amount of any given protein is governed by the rate of its creation versus destruction. A family of proteins called deubiquitylases (DUBs) is known to regulate the fate of specific proteins leading to either an increased or a decreased population size. We aim to identify particular DUBs that influence PD-L1 and EGFR and understand the mechanism by which they do so. By inhibiting these enzymes we will open up a new therapeutic strategy to reduce EGFR and/or PD-L1 levels.

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Grant Details

Amount Awarded 0
Applicant Surname Telnova
Approval Committee Internal Decision Panel
Award Date 2018-09-30T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title PhD Studentship (Basic)
Internal ID 203927/Z/16/A
Lead Applicant Miss Svetlana Telnova
Partnership Value 0
Planned Dates: End Date 2020-10-01T00:00:00+00:00
Planned Dates: Start Date 2017-10-02T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West