The CCC complex: an evolutionary conserved endosomal sorting complex (360G-Wellcome-203961_Z_16_A)

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The surface of all cells are coated with hundreds of different proteins that allow individual cells to signal to each other, attach to each other and sense the environment. These surface proteins are regularly internalised as part of normal cellular processes. For cells to remain healthy they must efficiently recycle some of these proteins back to the cell surface. To do this there are a number of multi-protein complexes that recognise the internalised proteins and select them for transport back to the cell surface. One such pathway is mediated by the recently identified retriever and CCC complexes. The aim of my PhD is to understand how these complexes interact with one another and how they recognise specific proteins to regulate their recycling. I will combine biochemical and molecular techniques with gene editing in cell culture to define the function of these multiprotein complexes. This is important because the recycling of cell surface proteins needs to be tightly regulated to ensure the correct levels are present. Failure to maintain the correct balance between degradation and recycling contributes to the pathogenesis of many neurodegenerative conditions including Parkinson's disease.

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Grant Details

Amount Awarded 0
Applicant Surname Chilton
Approval Committee Internal Decision Panel
Award Date 2018-09-30T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title PhD Studentship (Basic)
Internal ID 203961/Z/16/A
Lead Applicant Miss Molly Chilton
Partnership Value 0
Planned Dates: End Date 2020-10-18T00:00:00+00:00
Planned Dates: Start Date 2017-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South West