Synaptic dynamics underlying microcircuit plasticity in mouse barrel cortex (360G-Wellcome-203973_Z_16_A)

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Changes in the strength of connections between neurons, a phenomenon known as synaptic plasticity, are essential for brain function. By reshaping brain circuitry, animals learn from their experiences and adapt to their environment. Synaptic plasticity is especially relevant in sensory systems, as it allows to enhance or ignore stimuli according to their behavioural relevance. We aim to understand how sensory stimuli result in synaptic plasticity in neurons. For this, we will study responses of individual neurons in the mouse somatosensory cortex elicited by whisker stimulation, a type of sensory stimulus. A combination of electrophysiology and calcium imaging will be used to record cell activity at cellular and subcellular level. This will allow to determine which patterns of whisker stimulation result in synaptic plasticity and to study how the spatial arrangement, activation order and local interactions of synaptic inputs determine it. The observed input patterns will be replicated in neurons in brain slices and in a computational model to define the requirements for this type of plasticity. This project will help to understand the basic principles of synaptic plasticity and how sensory systems are adaptable to the environment.

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Grant Details

Amount Awarded 0
Applicant Surname Agullo Campello
Approval Committee Internal Decision Panel
Award Date 2018-09-30T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title PhD Studentship (Basic)
Internal ID 203973/Z/16/A
Lead Applicant Mr Juan Agullo Campello
Partnership Value 0
Planned Dates: End Date 2019-06-20T00:00:00+00:00
Planned Dates: Start Date 2017-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South West