Decoding adaptive immunity: high-throughput sequencing and characterisation of the immune repertoires produced during parasitic infections (360G-Wellcome-204511_Z_16_A)

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Despite extensive research, there remains no effective vaccine licensed for any human parasitic infections. This has been attributed to a lack of knowledge available regarding the development of naturally acquired immunity to such infections. Following pathogen exposure, clonal expansion of T and B-cells occurs, generating repertoires of lymphocytes that are a distinct response to the pathogen. High-throughput sequencing, in combination with proteomics, now provides the opportunity to study these immune responses in precise detail, delineating components of protective immunity and identifying their critical antigenic targets, providing unparalleled insights in to the mechanisms underlying immunity to a pathogen. By sequencing T and B-cell repertoires produced during parasitic infections, we aim to document conserved T cell and antibody responses that convey protection, and identify what antigens they are targeting, to inform vaccine design. Key goals are to provide proof of principle for this approach using a controlled animal-model of the malaria parasite Plasmodium chabaudi, before analysing human acquired immunity in Schistosomiasis. We aim to document TCR and antibody sequences that are elicited during immune responses to these parasitic infections, identify conserved ‘public’ antibody signatures generated and characterise their antigenic targets, thereby addressing the key knowledge gaps that have precluded effective vaccine design.

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Grant Details

Amount Awarded 0
Applicant Surname Smith
Approval Committee Internal Decision Panel
Award Date 2018-09-30T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title PhD Studentship (Basic)
Internal ID 204511/Z/16/A
Lead Applicant Dr Natasha Smith
Partnership Value 0
Planned Dates: End Date 2020-09-30T00:00:00+00:00
Planned Dates: Start Date 2017-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland