Prenatal malaria exposure and infant health and development: A prospective birth cohort study (PRiME) (360G-Wellcome-205324_Z_16_Z)

Recent evidence suggests that infants born to pregnancies exposed to malaria have more clinical malaria and anaemia following pre-natal exposure to malaria antigens leading, in some children to a blood-stage antigen tolerant phenotype that persists into childhood, yet in others to effective foetal immune priming. This may have important implications for malaria control and vaccination of children in endemic areas. We hypothesise that the timing and frequency of malaria infections during pregnancy affects the efficiency of foetal immune priming and the trans-placental transfer of antimalarial immunoglobulin and therewith the childhood susceptibility to malaria infections. Additionally, that adequate control of malaria during pregnancy may improve trans-placental transfer of protective antibodies to other infections, and potentially the vaccine immune responses to Extended Programme of Immunisation (EPI) related vaccines. Using mostly data from two upcoming funded studies linked to the Wellcome Trust, combined with assessment of vaccine immune responses, we will explore this in 1,123 infants born to HIV-negative pregnant women enrolled in a three-arm trial to determine the efficacy of novel Intermittent Preventive Treatment in pregnancy (IPT) These same infants will subsequently enroll into an observational cohort study to determine incidence of clinical malaria and other severe illnesses during early childhood.

Where is this data from?

This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.

Grant Details

Amount Awarded 143200
Applicant Surname Mategula
Approval Committee International Interview Committee
Award Date 2016-11-22T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title International Masters Fellowship
Internal ID 205324/Z/16/Z
Lead Applicant Dr Donnie Mategula
Partnership Value 143200
Planned Dates: End Date 2021-04-30T00:00:00+00:00
Planned Dates: Start Date 2017-08-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West
Sponsor(s) Dr. Matthew Chico, Prof Stephen Gordon