Prenatal malaria exposure and infant health and development: A prospective birth cohort study (PRiME) (360G-Wellcome-205324_Z_16_Z)
Recent evidence suggests that infants born to pregnancies exposed to malaria have more clinical malaria and anaemia following pre-natal exposure to malaria antigens leading, in some children to a blood-stage antigen tolerant phenotype that persists into childhood, yet in others to effective foetal immune priming. This may have important implications for malaria control and vaccination of children in endemic areas. We hypothesise that the timing and frequency of malaria infections during pregnancy affects the efficiency of foetal immune priming and the trans-placental transfer of antimalarial immunoglobulin and therewith the childhood susceptibility to malaria infections. Additionally, that adequate control of malaria during pregnancy may improve trans-placental transfer of protective antibodies to other infections, and potentially the vaccine immune responses to Extended Programme of Immunisation (EPI) related vaccines. Using mostly data from two upcoming funded studies linked to the Wellcome Trust, combined with assessment of vaccine immune responses, we will explore this in 1,123 infants born to HIV-negative pregnant women enrolled in a three-arm trial to determine the efficacy of novel Intermittent Preventive Treatment in pregnancy (IPT) These same infants will subsequently enroll into an observational cohort study to determine incidence of clinical malaria and other severe illnesses during early childhood.
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Grant Details
Amount Awarded | 143200 |
Applicant Surname | Mategula |
Approval Committee | International Interview Committee |
Award Date | 2016-11-22T00:00:00+00:00 |
Financial Year | 2016/17 |
Grant Programme: Title | International Masters Fellowship |
Internal ID | 205324/Z/16/Z |
Lead Applicant | Dr Donnie Mategula |
Partnership Value | 143200 |
Planned Dates: End Date | 2021-04-30T00:00:00+00:00 |
Planned Dates: Start Date | 2017-08-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | North West |
Sponsor(s) | Dr. Matthew Chico, Prof Stephen Gordon |