Clinical Study of the Effectiveness and Safety of Pronuclear Transplantation (360G-Wellcome-206001_Z_16_Z)

£201,869

Prof. Mary Herbert, Prof. Sir Doug Turnbull and colleagues published the first preclinical studies of pronuclear transplantation (PNT) on normally fertilised human zygotes in June 20161. In depth analysis revealed that "early PNT" does not adversely affect human development and greatly reduces the level of dysfunctional mitochondria in the embryo. This publication represents completion of the final scientific studies requested by the Human Fertlisation and Embryology Authority expert scientific review panel, paving the way for a clinical application to be submitted (likely in early autumn).2 Prof Turnbull now proposes to carry out a clinical study to evaluate the effectiveness and safety of mitochondrial donation in humans. The study will involve monitoring the fetal and postnatal development of 25 children conceived using the technique and to perform expert assessment of development in 5 areas (cognitive, motor, language, socio-emotional; and adaptive behaviour) at 18 months. The requested funding will cover clinical staff time, equipment, travel costs related to patient assessment and sample collection/analysis. Joint / collaborative funding At this stage exploration of mitochondrial donation includes both lab-based research and clinical research elements. It is therefore appropriate that the funding model reflects these different aspects. Following discussions, NHS England has agreed to meet treatment and clinical care costs as part of this research proposal, which represents the majority of the resource, with Wellcome funding the other components.

Where is this data from?

This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.

Grant Details

Amount Awarded 201869
Applicant Surname McFarland
Approval Committee Internal Decision Panel
Award Date 2016-09-30T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Discretionary Award – Science
Internal ID 206001/Z/16/Z
Lead Applicant Prof Robert McFarland
Partnership Value 201869
Planned Dates: End Date 2024-04-30T00:00:00+00:00
Planned Dates: Start Date 2017-05-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North East