Clinical Study of the Effectiveness and Safety of Pronuclear Transplantation (360G-Wellcome-206001_Z_16_Z)
Prof. Mary Herbert, Prof. Sir Doug Turnbull and colleagues published the first preclinical studies of pronuclear transplantation (PNT) on normally fertilised human zygotes in June 20161. In depth analysis revealed that "early PNT" does not adversely affect human development and greatly reduces the level of dysfunctional mitochondria in the embryo. This publication represents completion of the final scientific studies requested by the Human Fertlisation and Embryology Authority expert scientific review panel, paving the way for a clinical application to be submitted (likely in early autumn).2 Prof Turnbull now proposes to carry out a clinical study to evaluate the effectiveness and safety of mitochondrial donation in humans. The study will involve monitoring the fetal and postnatal development of 25 children conceived using the technique and to perform expert assessment of development in 5 areas (cognitive, motor, language, socio-emotional; and adaptive behaviour) at 18 months. The requested funding will cover clinical staff time, equipment, travel costs related to patient assessment and sample collection/analysis. Joint / collaborative funding At this stage exploration of mitochondrial donation includes both lab-based research and clinical research elements. It is therefore appropriate that the funding model reflects these different aspects. Following discussions, NHS England has agreed to meet treatment and clinical care costs as part of this research proposal, which represents the majority of the resource, with Wellcome funding the other components.
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Grant Details
Amount Awarded | 201869 |
Applicant Surname | McFarland |
Approval Committee | Internal Decision Panel |
Award Date | 2016-09-30T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Discretionary Award – Science |
Internal ID | 206001/Z/16/Z |
Lead Applicant | Prof Robert McFarland |
Partnership Value | 201869 |
Planned Dates: End Date | 2024-04-30T00:00:00+00:00 |
Planned Dates: Start Date | 2017-05-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | North East |