The cognitive neuroscience of over-eating: normative and clinical studies of goal-driven and stimulus-driven responses (360G-Wellcome-206368_Z_17_Z)

£1,500,053

There is a pressing need to understand the phenotypic variations of obesity in order to elucidate the diverse pathways and mechanisms by which it arises and, ultimately, to offer suitably tailored interventions. My proposed work aims to provide insights into the cognitive neuroscience of health-harming over-consumption. Its ultimate goals are to characterise cognitive mechanisms underlying eating behaviours, exploring how these are selected and deployed in ways that are shaped by both internal and environmental signals. The work is based on the view that obesity is ultimately driven by a complex integration of environmental and bodily signals and that a comprehensive approach must characterise this integration in order to determine how it may be altered in over-eating. My proposal has the following goals: To understand how stimulus-driven (automatic) and goal-directed (reflective) reward behaviours are balanced in relation to eating choices and to explore how this balance may differ across hungry and sated, lean and obese people. To relate these underlying processes to hormonal/metabolic signals as well and to real-world eating choices. To characterise the effects of three specific perturbations to this integrated system: (i) elective gastrectomy, (ii) single gene mutations affecting hypothalamic circuitry and (iii) psychopharmacological manipulations

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Grant Details

Amount Awarded 1500053
Applicant Surname Fletcher
Approval Committee Science Interview Panel
Award Date 2017-04-05T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Investigator Award in Science
Internal ID 206368/Z/17/Z
Lead Applicant Prof Paul Fletcher
Partnership Value 1500053
Planned Dates: End Date 2024-12-31T00:00:00+00:00
Planned Dates: Start Date 2018-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England