Innate immune cell signalling as a Cannabinoid target in Multiple Sclerosis (360G-Wellcome-206680_Z_17_Z)

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Currently there is no cure for MS and therapies focus on symptom management. Current treatments involve Sativex, a combination of plant-derived cannabinoids, tetrahydrocannabinol (THC) and cannabidiol (CBD), to alleviate MS-associated spasticity/pain. However, some patients do not respond to therapy and side effects have been identified. Hence, new data is needed to refine cannabinoid therapies, and by determining the precise cellular and molecular mechanisms of action of cannabinoids in blood cells isolated from patients, this proposal will assist the development of new targeted cannabinoid-based treatments that lack off-target effects. The proposal is designed to determine the cellular action of cannabinoids in patient cells by targeting innate immune receptors, including viral toll-like receptor (TLR)3 and bacterial TLR4 signalling mechanisms. The hypothesis is that targeting innate immune receptor signalling by plant-derived cannabinoids is a therapeutic avenue that may be exploited in the treatment of MS. Key goals: This work will contribute to the understanding of the inflammatory signalling mechanisms driven by TLR3 and TLR4 activation in human blood cells. This study will also determine if innate immune signalling responses are dysregulated in MS patient cells. Determine if plant-derived cannabinoids target inflammatory signalling mechanisms with relevance to MS at a cellular level.

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Grant Details

Amount Awarded 0
Applicant Surname Ryan
Approval Committee Internal Decision Panel
Award Date 2017-04-27T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Vacation Scholarships
Internal ID 206680/Z/17/Z
Lead Applicant Mr Tristram Ryan
Partnership Value 0
Planned Dates: End Date 2017-08-25T00:00:00+00:00
Planned Dates: Start Date 2017-06-26T00:00:00+00:00
Recipient Org: Country Ireland
Region Ireland