Space distortions: Towards a general framework of the hippocampal cognitive map (360G-Wellcome-206682_Z_17_Z)
A fundamental question in system neuroscience is where spatial cognition is generated and how it is used for navigation. Strong evidence points at the hippocampus as a cognitive map. Hippocampal place cells are active in restricted fields and hippocampal lesion impairs navigation. Recent experiments showed that spatial representations are also found in the entorhinal cortex, an interface between the hippocampus and neocortex. Entorhinal grid cells are active in many fields arranged in equilateral triangles. How these cells interact to provide a cognitive space remains elusive. It has been suggested that grid cells represent a spatial metric system and provide major inputs to the place cells. A number of recent experiments indicate a greater role of place cells in constructing grid cell pattern. Here, we propose to investigate how these cells interact and what role they play in navigation. We will test whether grid cells act as a spatial metric of the brain. Alternatively, we suggested that they could act as a matrix system conveying the information about the proximity of locations. Furthermore, we will study how single-cell perturbations affect interconnected grid-place cell network as well as an animal’s ability to navigate.
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Grant Details
Amount Awarded | 1377847 |
Applicant Surname | Krupic |
Approval Committee | Sir Henry Dale Fellowship Interview Committee |
Award Date | 2017-05-31T00:00:00+00:00 |
Financial Year | 2016/17 |
Grant Programme: Title | Sir Henry Dale Fellowship |
Internal ID | 206682/Z/17/Z |
Lead Applicant | Dr Julija Krupic |
Partnership Name | Royal Society/Wellcome Trust Sir Henry Dale Fellowship |
Partnership Value | 1377847 |
Planned Dates: End Date | 2024-08-11T00:00:00+00:00 |
Planned Dates: Start Date | 2017-11-07T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof William Harris |