An Assessment of Neuroinflammation in Parkinson's Disease Patients (360G-Wellcome-206847_Z_17_Z)

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Parkinson’s Disease (PD) is the most common motor-related neurogenerative disease, with numbers expected to increase annually due to an ageing population. PD patients suffer with motor dysfunction due to a reduction of brain dopamine levels. Dopaminergic neurone degeneration occurs in tandem with alpha-synuclein protein aggregate deposition. These alpha-synuclein protein aggregates are thought to contribute to neuroinflammation, and a neurodegenerative phenotype in PD. The aim of this project is to compare the prefrontal cortex brain tissue of PD patients with that of age and sex matched control subjects to investigate inflammation levels. This will be achieved by quantifying the levels of proinflammatory factors IL-1, TNFalpha, IL-6, IL-8 and NLRP3 inflammasome components present in control vs. PD tissue. Quantification of the inflammatory factors will be achieved using ELISAs and Western Blotting techniques. The discovery of evidence demonstrating increased inflammation in PD brain tissue would further reinforce the justification for current, and future, use of anti-inflammatory agents to reduce damaging neuroinflammation.

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Grant Details

Amount Awarded 0
Applicant Surname Carlisle
Approval Committee Internal Decision Panel
Award Date 2017-04-27T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Vacation Scholarships
Internal ID 206847/Z/17/Z
Lead Applicant Mr Paul Carlisle
Partnership Value 0
Planned Dates: End Date 2017-08-04T00:00:00+00:00
Planned Dates: Start Date 2017-06-05T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East Midlands