Role of TRPC4 in regulating human myometrium contractions in vitro (360G-Wellcome-206880_Z_17_Z)

£0

An estimated 15 million preterm births occur worldwide every year, associated with over a million neonatal deaths and a high incidence of physical and neurodevelopmental disability amongst surviving infants throughout their life course. In the ‘Born too Soon’ Global Action Report (2012), the World Health Organisation concluded that ‘much more knowledge is needed to address the solution and reach a point where preterm birth is prevented’. This vacation studentship focuses on understanding how pregnant human uterine smooth muscle functions in order to inform the development of tocolytic therapies for the prevention of spontaneous preterm labour and hence preterm birth. Specifically, the project will assess the contribution of TRPC4 channels (non selective cation channels that are implicated in store operated calcium entry) to the regulation of spontaneous and oxytocin induced contractile activity in human myometrium. Hypothesis and aims It is hypothesised that TRPC4 augments human myometrial contraction amplitude and frequency. The overall goal is to assess the actions of two TRPC4 channel inhibitors on spontaneously and oxytocin stimulated pregnant human myometrium obtained at the time of caesarean section. The results will help confirms or refute the hypothesis and described the role of TRPC4 in human myometrium.

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Grant Details

Amount Awarded 0
Applicant Surname Phillips
Approval Committee Internal Decision Panel
Award Date 2017-04-27T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Vacation Scholarships
Internal ID 206880/Z/17/Z
Lead Applicant Miss Jemima Phillips
Partnership Value 0
Planned Dates: End Date 2017-08-04T00:00:00+00:00
Planned Dates: Start Date 2017-06-05T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London