The research aims to quantitatively assess biomarkers of reperfusion injury after induction of focal cerebral ischaemia in rats by occluding the middle cerebral artery, subsequently reperfusing it for 2 or 4 hours. The brain sections of the rats are then analysed to look at the extent of haemorrhage with the dysfunction of the blood brain barrier which causes biomarkers to be released. The results can then be used to measure which biomarker indicate greater reperfusion injury as well as the effectiveness of different reperfusion strategies in stroke.
Where is this data from?
This data was originally published by
The Wellcome Trust.
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