Microanatomy of the thumb carpometacarpal (1CMC) joint. (360G-Wellcome-206948_Z_17_Z)

The 1CMCjoint is the joint in the hand most affected by osteoarthritis.However there is only limited information available on its microscopic structure, and the studies which have been performed are difficult to compare as they all utilise different techniques(CT, MRI, SEM).In work as yet unpublished (Wilkins) it demonstrated the feasibility of obtaining joints and imaging them by eSEM to give high resolution surface maps of the articular surfaces, comparable to those obtained in standard SEM.This project was commenced to attempt to integrate and correlate information from several of these techniques. The joints were then reprocessed for routine paraffin histology and the appearance of the joint surface correlated with the morphology of the articular cartilage and subchondral bone in histological sections.This is the first time that direct correlation of the joint surface with joint histology has been demonstrated.This project aims to extend these studies to include micro CT in the examination sequence.Radiographic and CT imaging are clinically useful in assessing joint disease. On successful completion this will enable direct correlation of clinically relevant imaging data with high resolution views of the joint surface and the cartilage bone interface.

Where is this data from?

This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.

Grant Details

Amount Awarded 0
Applicant Surname Ní Chorráin
Approval Committee Internal Decision Panel
Award Date 2017-04-27T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Vacation Scholarships
Internal ID 206948/Z/17/Z
Lead Applicant Miss Niamh Ní Chorráin
Partnership Value 0
Planned Dates: End Date 2017-08-05T00:00:00+00:00
Planned Dates: Start Date 2017-06-06T00:00:00+00:00
Recipient Org: Country Ireland
Region Ireland