Nociceptive and anti-nociceptive actions of Cnidaria toxins. (360G-Wellcome-206958_Z_17_Z)

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Chronic pain is prevalent, affecting 20% of adults (eg https://www.ncbi.nlm.nih.gov/books/NBK92525/). It is poorly controlled by existing therapies because of limited efficacy or very significant side effects. We know that most chronic pain can be relieved – at least temporarily – by local anaesthetic blockade of peripheral nerves. Genetic studies have identified some ion channels that are specifically expressed in sensory neurones that, when mutated, cause either congenital analgesia (total absence of pain sensibility, specifically seen with mutations in Nav1.7) or episodic spontaneous pain. Natural occurring toxins and venoms have been found to have a range of actions on these peripherally expressed ion channels. For instance, Omega-Conotoxin from cone snails is a selective calcium channel blocker that has found limited use (because of side effects) in the treatment of intractable pain. Cnidaria (jellyfish, corals etc.) are amongst the most iconic residents of the sea and are arguably the most primitive of venomous animals, yet their venoms have never been screened for neurotoxic compounds. This project will test the hypothesis that Cnidarian toxins will affect affect the excitability of adult rodent nociceptors studied in vitro.

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Grant Details

Amount Awarded 0
Applicant Surname Andreica
Approval Committee Internal Decision Panel
Award Date 2017-04-27T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Vacation Scholarships
Internal ID 206958/Z/17/Z
Lead Applicant Ms Elena-Cristina Andreica
Partnership Value 0
Planned Dates: End Date 2017-08-20T00:00:00+00:00
Planned Dates: Start Date 2017-06-21T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London