Investigating a new model of neurodegenerative disease (360G-Wellcome-207007_Z_17_Z)
Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative disorders characterised by degeneration of the longest motor neurons which leads to muscle weakness and spasticity in the lower limbs. There are currently no treatments to cure or even to slow the course of these diseases. In this project I will test a novel in vivo model of HSP generated by CRISPR/Cas9 gene editing in Drosophila. I will investigate gene and protein expression, locomotor behaviours and motor neuron endoplasmic reticulum (ER) organisation. My research will determine how HSP-causing mutations affect endoplasmic reticulum organisation and neuronal function. The results from this project will validate a novel model of HSP and will further our understanding of the molecular mechanisms underpinning this neurodegenerative disorder.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
| Amount Awarded |
0
|
| Applicant Surname | Doyle |
| Approval Committee | Internal Decision Panel |
| Award Date | 2017-04-27T00:00:00+00:00 |
| Financial Year | 2016/17 |
| Grant Programme: Title | Vacation Scholarships |
| Internal ID | 207007/Z/17/Z |
| Lead Applicant | Mr Ruairi Doyle |
| Partnership Value | 0 |
| Planned Dates: End Date | 2017-09-02T00:00:00+00:00 |
| Planned Dates: Start Date | 2017-07-03T00:00:00+00:00 |
| Recipient Org: Country | Ireland |
| Region | Ireland |