Characterising the Anti-inflammatory Properties of Cordycepin (360G-Wellcome-207240_Z_17_Z)

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Cordycepin is an extract that is purified and isolated from Cordyceps Militaris, a specific strain of caterpillar fungus. It is commonly found in traditional Chinese medicine however my research aims to determine whether the compound may also be implemented in conventional medicines for the treatment of cancers and inflammatory diseases. My supervisor has already established that cordycepin down-regulates gene expression by inhibiting the polyadenylation step involved in the formation of the mRNA transcript. However, I will be investigating the effects of cordycepin on the metabolic activity and the translocation of a particular transcription factor associated with stimulating the expression of inflammatory genes in tissue culture samples containing macrophage-like haemocytes. This will be compared to other fungal extracts of insect-infecting and non-insect infecting origin to identify whether suppression of the anti-inflammatory response is replicated across a range of these compounds. Various analytical techniques will be employed such as MTT assaying and immunohistochemistry. The end results of my study will allow me to conclude how cordycepin affects the immune response and whether certain fungal extracts can be used in new immunosuppressive drugs for the future.

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Grant Details

Amount Awarded 0
Applicant Surname Vahabi
Approval Committee Internal Decision Panel
Award Date 2017-04-27T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Vacation Scholarships
Internal ID 207240/Z/17/Z
Lead Applicant Mr Amir Vahabi
Partnership Value 0
Planned Dates: End Date 2017-09-16T00:00:00+00:00
Planned Dates: Start Date 2017-07-17T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East Midlands