Phenotyping regulatory B cells in the microenvironment of Hodgkin lymphoma (360G-Wellcome-207449_Z_17_Z)

£0

The role of malignant B cells in Hodgkin lymphoma is unknow. Recent studies in Birmingham have provided preliminary evidence that non-malignant B cells frequently infiltrate the tissue of Hodgkin’s lymphoma. Furthermore, previous studies reported the clinical benefit of Rituximab, with CD20 negative tumour cells, which was unanticipated as it is a therapy targeted to CD20 positive cells. This suggested that non-tumour B cells promote tumour cell survival. Moreover, my supervisor's lab has recently optimised highly sensitive in situ hybridisation to detect in tissue sections the immunosuppressive cytokine IL-10, widely established as a marker of a subset of regulatory B cells. Taking these findings into consideration I am to: Characterise the non-tumour B cell population of Hodgkin’s lymphoma Determine the extent to which the phenotype of non-malignant B cells in Hodgkin’s lymphoma varies with tumour subtype and EBV status To determine the extent at which Hodgkin’s lymphoma xenografts recapitulate B cell infiltration in a humanised mouse model

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Grant Details

Amount Awarded 0
Applicant Surname Roy
Approval Committee Internal Decision Panel
Award Date 2017-04-27T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Vacation Scholarships
Internal ID 207449/Z/17/Z
Lead Applicant Mr Pranjal Roy
Partnership Value 0
Planned Dates: End Date 2017-08-01T00:00:00+00:00
Planned Dates: Start Date 2017-06-02T00:00:00+00:00
Recipient Org: Country United Kingdom
Region West Midlands