Understanding mechanisms that drive pain perception in early human development (360G-Wellcome-207457_Z_17_A)
Pain in infancy has negative long-term consequences and its prevention is a clinical priority, but adequate treatment requires mechanistic understanding of the structural and functional development of human nociceptive circuitry. Recent scientific and technological advances provide insights into how noxious information is transmitted to the infant brain, providing a platform to ask how intrinsic brain network connectivity and the environment affect noxious-evoked brain activity, behaviour and ultimately pain perception in the developing infant nervous system. The fellowship goal is to understand the mechanisms that drive and modulate pain perception in early human development. I will ask whether inherent differences in how the brain behaves at rest influence variability in noxious-evoked activity, and will determine how this relationship is altered by environmental factors and pathology. I will establish how the development of structural and functional network connectivity alters noxious-evoked brain activity, and influences the dynamic relationship between brain activity and behaviour. I will translate this mechanistic understanding into clinical practice by conducting a clinical trial of an analgesic (fentanyl) during a minor surgical procedure, and will establish whether our newly-developed measures of noxious-evoked brain activity are suitable for use in infant analgesic dose-finding studies.
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Grant Details
Amount Awarded | 60000 |
Applicant Surname | Slater |
Approval Committee | Science Interview Panel |
Award Date | 2017-07-11T00:00:00+00:00 |
Financial Year | 2016/17 |
Grant Programme: Title | Provision for Public Engagement |
Internal ID | 207457/Z/17/A |
Lead Applicant | Prof Rebeccah Slater |
Partnership Value | 60000 |
Planned Dates: End Date | 2024-12-01T00:00:00+00:00 |
Planned Dates: Start Date | 2017-12-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |
Sponsor(s) | Prof Georg Holländer |