Identifying the mechanisms of insecticide resistance in Anopheles gambiae s.s. and Anopheles arabiensis in Chikwawa, Malawi (360G-Wellcome-208292_Z_17_Z)

Malaria is a major cause of morbidity and mortality in Malawi. There has been an increase in the use of insecticides for malaria control either through Long Lasting Insecticide Treated Bednets or Insecticide Residual Spraying. Insecticide resistance in the primary malaria vectors has been reported and may impact the efficacy of current anti-vector control strategies. To maximise the efficacy and to ensure continued use of these insecticides it is necessary for the National Malaria Control Programme (NMCP) to develop an Insecticide Resistance Management (IRM) plan. The IRM plan will be most effective if we have detailed understanding of the genes which are associated with the resistance phenotype. My project aims to use transcriptomic approaches to characterise expression patterns linked to insecticide resistance in Anopheles gambiae s.s. and An. arabiensis in Chikwawa, an area of high malaria transmission. The study will establish the resistance patterns in the common malaria vectors and the molecular markers which can be used to predict and manage insecticide resistance.

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Grant Details

Amount Awarded 147484
Applicant Surname Tchongwe-Divala
Approval Committee International Interview Committee
Award Date 2017-06-19T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title International Masters Fellowship
Internal ID 208292/Z/17/Z
Lead Applicant Mrs Lizzie Tchongwe-Divala
Partnership Value 147484
Planned Dates: End Date 2020-12-03T00:00:00+00:00
Planned Dates: Start Date 2017-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West
Sponsor(s) Prof Martin Donnelly, Prof Stephen Gordon