3D bioprinting for enhanced biosensing, regenerative medicine and pharmaceutical manufacture (360G-Wellcome-208366_Z_17_Z)

£155,000

The GeSiM BioScaffolder 3.1 printer is a flexible 3D bio-printer with a unique piezoelectric micro-pipetting system for pico- and nano-litre spotting of cells and biomolecules, as well as pneumatically-actuated cartridges for precise printing of highly viscous materials (e.g. molten polymers) on definable coordinates within a scaffold structure or on flat surfaces. This combination of both technologies is unique and not available on competitor 3D printers. The BioScaffolder can print polymers at temperatures up to 250°C, while cells and biomolecules (e.g. enzymes, proteins) can be maintained at 37°C. This innovative approach allows struts of mechanically-stiff materials to be combined with cell-friendly materials (e.g. hydrogels) containing suspended cells in novel regenerative medicine approaches. The instrument automatically aligns print tools of different dimensions by means of a 3-axis light barrier. Struts of up to three different materials can be combined, even in a single layer. Individual cells, cell suspensions and aqueous polymer solutions can be printed onto substrates for applications in single-cell analyses, biosensing and drug delivery. Importantly, the Bioscaffolder can be interfaced with existing analytical equipment, with individual cells or solutions printed directly into instrument sample holders, or onto microfluidic chips or biosensor substrates.

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Grant Details

Amount Awarded 155000
Applicant Surname Donnelly
Approval Committee Multi-User Equipment and Technology Development Committee
Award Date 2017-07-06T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Multi-User Equipment Grant
Internal ID 208366/Z/17/Z
Lead Applicant Prof Ryan Donnelly
Other Applicant(s) Dr Cuong Cao, Dr Eneko Larraneta, Dr Peter Boyd, Dr Raghu Thakur, Prof Brendan Gilmore, Prof Cecilia O'Kane, Prof Daniel Longley, Prof Fraser Buchanan, Prof Steven Bell
Partnership Value 155000
Planned Dates: End Date 2023-03-28T00:00:00+00:00
Planned Dates: Start Date 2018-03-28T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Northern Ireland