Light sheet microscope for 3D imaging of large samples and improved in vivo imaging (360G-Wellcome-208373_Z_17_Z)

£414,588

We are requesting funds to purchase a light sheet microscope that will be used as multi-user equipment by the applicants. The equipment is based on a technology that has two main advantages over other methods of fluorescence microscopy currently available to us. These advantages will enhance our research in a wide variety of different applications. First, light sheet microscopy can acquire optical images at very high speeds, and thus data collection of large samples becomes rapid and efficient. This will allow us to rapidly image very thick samples including small whole organisms (zebrafish and drosophila larvae, for example) and intact mouse brains. Second, light sheet microscopy substantially reduces photodamage to living samples compared to other imaging approaches because it only illuminates a small plane of the sample during image acquisition. This will allow us to image living samples for longer periods or increase our temporal resolution while imaging for shorter periods. The ten applicant groups, seven of which are currently funded by the Wellcome Trust, will be the primary users of this equipment. This number of researchers will maximise use of the equipment while guaranteeing sufficient hours for each group.

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Grant Details

Amount Awarded 414588
Applicant Surname Marín
Approval Committee Multi-User Equipment and Technology Development Committee
Award Date 2017-07-06T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Multi-User Equipment Grant
Internal ID 208373/Z/17/Z
Lead Applicant Prof Oscar Marín
Other Applicant(s) Dr Laura Andreae, Dr Martin Meyer, Prof Beatriz Rico, Prof Brian Stramer, Prof David Edwards, Prof Jon Clarke, Prof Juan Burrone, Prof Phillip Gordon-Weeks, Prof Robert Hindges
Partnership Value 414588
Planned Dates: End Date 2023-10-16T00:00:00+00:00
Planned Dates: Start Date 2018-10-16T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London