Light sheet microscope for 3D imaging of large samples and improved in vivo imaging (360G-Wellcome-208373_Z_17_Z)
We are requesting funds to purchase a light sheet microscope that will be used as multi-user equipment by the applicants. The equipment is based on a technology that has two main advantages over other methods of fluorescence microscopy currently available to us. These advantages will enhance our research in a wide variety of different applications. First, light sheet microscopy can acquire optical images at very high speeds, and thus data collection of large samples becomes rapid and efficient. This will allow us to rapidly image very thick samples including small whole organisms (zebrafish and drosophila larvae, for example) and intact mouse brains. Second, light sheet microscopy substantially reduces photodamage to living samples compared to other imaging approaches because it only illuminates a small plane of the sample during image acquisition. This will allow us to image living samples for longer periods or increase our temporal resolution while imaging for shorter periods. The ten applicant groups, seven of which are currently funded by the Wellcome Trust, will be the primary users of this equipment. This number of researchers will maximise use of the equipment while guaranteeing sufficient hours for each group.
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Grant Details
Amount Awarded | 414588 |
Applicant Surname | Marín |
Approval Committee | Multi-User Equipment and Technology Development Committee |
Award Date | 2017-07-06T00:00:00+00:00 |
Financial Year | 2016/17 |
Grant Programme: Title | Multi-User Equipment Grant |
Internal ID | 208373/Z/17/Z |
Lead Applicant | Prof Oscar Marín |
Other Applicant(s) | Dr Laura Andreae, Dr Martin Meyer, Prof Beatriz Rico, Prof Brian Stramer, Prof David Edwards, Prof Jon Clarke, Prof Juan Burrone, Prof Phillip Gordon-Weeks, Prof Robert Hindges |
Partnership Value | 414588 |
Planned Dates: End Date | 2023-10-16T00:00:00+00:00 |
Planned Dates: Start Date | 2018-10-16T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |