Mass spectrometry infrastructure underpinning research into the molecular basis and biological mechanisms in health and disease (360G-Wellcome-208385_Z_17_Z)

£415,000

Funding of £715k is requested as a 50% contribution to the purchase of three mass spectrometers in Leeds: 1) Orbitrap Q-Exactive Plus-EMR (collaboration with Thermo Scientific; high-mass modified for membrane protein/lipid studies and top-down protein characterization); 2) Tofwerk high-resolution ion-mobility platform, allowing acquisition of unprecedented conformational detail of dynamic protein structure and ligand interactions; 3) Orbitrap Q-Exactive Plus for providing a major upgrade to the proteomics capabilities. The instruments will include associated nano-LC systems, software, processors and extended maintenance contracts. This equipment will revolutionise current capabilities in biomolecular characterization and quantification using mass spectrometry (MS)-based technologies, impacting on translational medicine through mechanistic studies, biomarker discovery and drug development. The new state-of-the-art platforms will extend analysis capabilities in membrane protein structure, "top-down" analysis of post-translational modification and ligand binding, and conformational and (mis-)folding studies. The replacement of an aged unreliable Orbitrap MS will allow considerably faster proteomic data acquisition with higher resolution and sensitivity and lower sample requirements, and exploratory metabolomics. Forming part of a virtual, Leeds-wide facility for MS with complementary centres of expertise at the Astbury Centre on the main campus and at the St James’s University hospital (SJUH) campus, beneficiaries span the Life, Medical and Physical Sciences.

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Grant Details

Amount Awarded 415000
Applicant Surname Sobott
Approval Committee Multi-User Equipment and Technology Development Committee
Award Date 2017-07-06T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Multi-User Equipment Grant
Internal ID 208385/Z/17/Z
Lead Applicant Prof Frank Sobott
Other Applicant(s) Dr Megan Wright, Dr Stephen Muench, Prof Andrew Macdonald, Prof Ann Morgan, Prof David Beech, Prof Mark Harris, Prof Peter Selby, Prof Rosamonde Banks, Prof Sheena Radford
Partnership Value 415000
Planned Dates: End Date 2022-09-01T00:00:00+00:00
Planned Dates: Start Date 2017-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Yorkshire and the Humber