Maintaining a unique parasite life cycle and development of post-genomic resources (360G-Wellcome-208390_Z_17_Z)
This proposal has two key goals focussing on the filarial nematode Brugia pahangi, representative of a parasite group which infects over 100M people in low/middle income countries and responsible for lymphatic filariasis and onchocerciasis. The aims are firstly to maintain the life cycle of Brugia pahangi, the sister species of the human infective parasite Brugia malayi, and secondly, to develop post-genomic experimental resources for better understanding of gene function in filarial nematodes. Currently the Devaney lab is the only lab known to maintain the life cycle of the original type specimen of B. pahangi, and this life cycle has become an important source of material for many researchers in the UK/Europe. The second aim of the project is to provide parasites for the development of a range of basic molecular cell biology resources, including methods for microinjection of filarial worms and the development of filarial cell lines. Although we have excellent genome sequence from a range of filarial worms (including the Glasgow B. pahangi), progress in the field suffers from the lack of genomic tools for interrogating gene function; there is no doubt that the development of such methods would provide a major resource for scientists worldwide.
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Grant Details
Amount Awarded | 207015 |
Applicant Surname | Devaney |
Approval Committee | Biomedical Resource Committee |
Award Date | 2017-07-06T00:00:00+00:00 |
Financial Year | 2016/17 |
Grant Programme: Title | Biomedical Resources Grant |
Internal ID | 208390/Z/17/Z |
Lead Applicant | Prof Eileen Devaney |
Partnership Value | 207015 |
Planned Dates: End Date | 2022-01-01T00:00:00+00:00 |
Planned Dates: Start Date | 2017-09-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Scotland |