Maintaining a unique parasite life cycle and development of post-genomic resources (360G-Wellcome-208390_Z_17_Z)

£207,015

This proposal has two key goals focussing on the filarial nematode Brugia pahangi, representative of a parasite group which infects over 100M people in low/middle income countries and responsible for lymphatic filariasis and onchocerciasis. The aims are firstly to maintain the life cycle of Brugia pahangi, the sister species of the human infective parasite Brugia malayi, and secondly, to develop post-genomic experimental resources for better understanding of gene function in filarial nematodes. Currently the Devaney lab is the only lab known to maintain the life cycle of the original type specimen of B. pahangi, and this life cycle has become an important source of material for many researchers in the UK/Europe. The second aim of the project is to provide parasites for the development of a range of basic molecular cell biology resources, including methods for microinjection of filarial worms and the development of filarial cell lines. Although we have excellent genome sequence from a range of filarial worms (including the Glasgow B. pahangi), progress in the field suffers from the lack of genomic tools for interrogating gene function; there is no doubt that the development of such methods would provide a major resource for scientists worldwide.

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Grant Details

Amount Awarded 207015
Applicant Surname Devaney
Approval Committee Biomedical Resource Committee
Award Date 2017-07-06T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Biomedical Resources Grant
Internal ID 208390/Z/17/Z
Lead Applicant Prof Eileen Devaney
Partnership Value 207015
Planned Dates: End Date 2022-01-01T00:00:00+00:00
Planned Dates: Start Date 2017-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland