HWB-NMR: a national resource for biomolecular research (360G-Wellcome-208400_Z_17_Z)

We are committed to ensuring that the UK remains world-leading in the field of biomolecular NMR spectroscopy and request support to continue offering the UK's only cryoprobe-equipped 900MHz NMR spectrometer and a 600MHz TXO cryoprobe as an open access resource to the UK biomolecular NMR community. HWB-NMR has continued to maintain and support an established national user base of ~50 groups, whose research has been published in high profile publications including Nature Chem Biol, Nature Commun, JACS, Angew Chem, Science, Cell Reports. The funding will allow us to dedicate 70% of available spectrometer time to external UK-based academic users, and to provide training to the next generation of researchers through hands-on spectrometer use and courses, as well as valuable networking opportunities at annual user meetings. We also request support to upgrade our 12-year old Agilent 800MHz instrument that we would like to equip with an ultra-sensitive low-volume cryoprobe and an autosampler to become a UK resource targeted towards innovative NMR applications for metabolism-related projects, while remaining accessible for structural biology and structure-based drug discovery. An instrument optimised for mass-limited samples at physiologically-relevant salt levels would increase our capability in fields of significant demand and scientific impact.