Neural circuitry and neurochemistry of decision making (360G-Wellcome-208789_Z_17_Z)

£919,348

My proposed research aims to understand the neural circuitry and neurochemistry of human decision making. Changes in the neurochemistry of prefrontal cortex can directly influence motivational and decision making behaviours. The circuit mechanisms by which this occurs remain unclear, but clarifying these mechanisms is important because it will help to bridge molecular and behavioural explanations of decision making. This will inform our understanding of several neuropsychiatric disorders that feature neurochemical (i.e. molecular-level) changes as part of their aetiology, and altered decision making behaviours as a cardinal symptom. My research has three main goals. First, I will develop novel neuroimaging-based measures of neural circuit computations within decision making tasks. Second, I will validate these measures via collaboration with researchers collecting non-human primate data. Third, I will use pharmacological interventions as a tool to understand the effects of neurochemical circuit manipulations in both species. This project aims to provide a holistic understanding of the neural circuitry and neurochemistry of decision making in the healthy brain. Ultimately, this work may provide the foundations required to index and understand neural circuit dysfunction in neuropsychiatric patients.

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Grant Details

Amount Awarded 919348
Applicant Surname Hunt
Approval Committee Sir Henry Dale Fellowship Interview Committee
Award Date 2017-10-18T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Sir Henry Dale Fellowship
Internal ID 208789/Z/17/Z
Lead Applicant Dr Laurence Hunt
Partnership Name Royal Society/Wellcome Trust Sir Henry Dale Fellowship
Partnership Value 919348
Planned Dates: End Date 2024-04-02T00:00:00+00:00
Planned Dates: Start Date 2018-04-02T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof John Geddes