Neural circuitry and neurochemistry of decision making (360G-Wellcome-208789_Z_17_Z)
My proposed research aims to understand the neural circuitry and neurochemistry of human decision making. Changes in the neurochemistry of prefrontal cortex can directly influence motivational and decision making behaviours. The circuit mechanisms by which this occurs remain unclear, but clarifying these mechanisms is important because it will help to bridge molecular and behavioural explanations of decision making. This will inform our understanding of several neuropsychiatric disorders that feature neurochemical (i.e. molecular-level) changes as part of their aetiology, and altered decision making behaviours as a cardinal symptom. My research has three main goals. First, I will develop novel neuroimaging-based measures of neural circuit computations within decision making tasks. Second, I will validate these measures via collaboration with researchers collecting non-human primate data. Third, I will use pharmacological interventions as a tool to understand the effects of neurochemical circuit manipulations in both species. This project aims to provide a holistic understanding of the neural circuitry and neurochemistry of decision making in the healthy brain. Ultimately, this work may provide the foundations required to index and understand neural circuit dysfunction in neuropsychiatric patients.
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Grant Details
Amount Awarded | 919348 |
Applicant Surname | Hunt |
Approval Committee | Sir Henry Dale Fellowship Interview Committee |
Award Date | 2017-10-18T00:00:00+00:00 |
Financial Year | 2017/18 |
Grant Programme: Title | Sir Henry Dale Fellowship |
Internal ID | 208789/Z/17/Z |
Lead Applicant | Dr Laurence Hunt |
Partnership Name | Royal Society/Wellcome Trust Sir Henry Dale Fellowship |
Partnership Value | 919348 |
Planned Dates: End Date | 2024-04-02T00:00:00+00:00 |
Planned Dates: Start Date | 2018-04-02T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |
Sponsor(s) | Prof John Geddes |