Identifying the drivers of insecticide resistance in Brazilian Aedes aegypti (360G-Wellcome-209305_Z_17_Z)

At present, four major arboviruses are transmitted by Aedes aegypti mosquitoes, with Brazil a focus of the disease burden. Due to the absence of antiviral therapies and effective candidate vaccines, vector control via insecticide-based approaches remain the chiefly form of disease intervention. The increase in insecticide resistance due to overuse/misuse of insect-killing chemicals has threatened these vector control strategies. This proposal aims to address the knowledge gap in Brazilian Ae. aegypti with respect to the critical issue of the evolution of insecticide resistance and how unregulated use of domestic insecticides is exerting a selection pressure, which may be driving resistance. We will: I) investigate how household insecticides select for mechanisms of resistance/cross-resistance to pyrethroids in Ae. aegypti; II) Perform the first Brazilian Ae. aegypti pyrethroid-resistant RNA-seq transcriptomic profiling to identify gene sets underlying resistance to complex mixtures typical of household products, and III) Develop molecular diagnostic assays to predict the efficacy of vector control interventions based on a validated suite of metabolic-resistance markers. The results from this work will contribute to a better understanding of the genetic basis of resistance in Brazilian Ae. aegypti, while also providing new insights on how indiscriminate use of household insecticides contribute to increased insecticide-resistance.

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Grant Details

Amount Awarded 312914
Applicant Surname Silva Martins
Approval Committee International Interview Committee
Award Date 2017-11-21T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title International Training Fellowship
Internal ID 209305/Z/17/Z
Lead Applicant Dr Walter Fabricio Silva Martins
Partnership Value 312914
Planned Dates: End Date 2024-07-01T00:00:00+00:00
Planned Dates: Start Date 2018-07-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West
Sponsor(s) Dr Constancia Junqueira Ayres Lopes, Prof Martin Donnelly