What makes phleboviruses tick? Examining the molecular interactions of tick-borne phleboviruses with their arthropod vector. (360G-Wellcome-210462_Z_18_Z)
There is a fundamental lack of understanding regarding how tick-borne viruses replicate in ticks and how the tick innate immune system controls infection. My proposal will focus on tick-borne SFTS phlebovirus, its overarching goals are to understand how tick-borne viruses interact with ticks and tick cells and how this facilitates transmission to mammalian hosts. To achieve my goals, I will carry out in vitro and in vivo studies that can be divided into three specific aims: (i) to elucidate the basic molecular biology of tick-borne virus replication, (ii) to define the innate immune factors that control virus replication in the tick cell environment and (iii) to examine whether virions derived from tick or mammalian cells have similar biological properties and virulence? I will conduct in vitro experiments in tick cell lines to examine virus-vector interactions. Importantly, I will also establish unique tick colonies and infection capabilities for the UK. Through combined cell culture approaches and in vivo animal experiments I will investigate the replication of phleboviruses in the live tick for the first time. I will also explore the infectivity of virions derived from different sources and assess if tick-derived viruses are more virulent to mammals in animal inoculation studies.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
Amount Awarded | 1335592 |
Applicant Surname | Brennan |
Approval Committee | Sir Henry Dale Fellowship Interview Committee |
Award Date | 2018-02-21T00:00:00+00:00 |
Financial Year | 2017/18 |
Grant Programme: Title | Sir Henry Dale Fellowship |
Internal ID | 210462/Z/18/Z |
Lead Applicant | Dr Benjamin Brennan |
Partnership Name | Royal Society/Wellcome Trust Sir Henry Dale Fellowship |
Partnership Value | 1335592 |
Planned Dates: End Date | 2024-09-03T00:00:00+00:00 |
Planned Dates: Start Date | 2018-09-03T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Scotland |
Sponsor(s) | Prof Massimo Palmarini |