Dengue Controlled Human Infection Model - Development Grant (360G-Wellcome-210607_Z_18_Z)

£23,690

Following a positive response to the preliminary submission for grant funding to establish a Dengue Controlled Human Infection Model (Dengue-CHIM ) in Ho Chi Minh City, Vietnam, I am submitting this request for a small grant to assist in refining and developing the main proposal prior to final submission in March 2018. During this pre-submission phase I plan to employ an experienced post-doctoral immunologist to carry out a) a scoping review of the current landscape of dengue vaccines in development, and b) a review exploring the current understanding of the immune response to/protection from DENV infection and disease, particularly focusing on immune correlates of protection. This will be the first application of a Dengue-CHIM approach in any dengue endemic setting, and raises a number of important bioethical concerns. Therefore I also plan to employ a Vietnamese social science research assistant for a period of 4 months to engage with key Vietnamese stakeholders to discuss the important issues surrounding endemic setting CHIMs, conduct preliminary informal interviews with these individuals, and help to develop the agenda for a 2 day workshop focused on Bioethics and Stakeholder Engagement related to endemic setting CHIMs that will take place in early March.

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Grant Details

Amount Awarded 23690
Applicant Surname Wills
Approval Committee Internal Decision Panel
Award Date 2017-11-17T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Discretionary Award - Vaccines
Internal ID 210607/Z/18/Z
Lead Applicant Prof Bridget Wills
Partnership Value 23690
Planned Dates: End Date 2018-07-31T00:00:00+00:00
Planned Dates: Start Date 2017-12-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East