Memory and language in synchrony: The role of theta oscillations in binding multisensory speech in memory. (360G-Wellcome-210924_Z_18_Z)
How does the brain process auditory and visual streams at a time to form multisensory memories of conversations? In real-life, speech is often audiovisual and brain oscillations are entrained in the theta band by tracking the syllabic structure conveyed at ~4Hz in both modalities (i.e. utterance and corresponding lip movements). Additionally, theta activity has been shown to be the most dominant oscillatory activity in the hippocampus and to support episodic memory formation. This proposal addresses multisensory speech and memory processes, which have rarely been studied together within an oscillatory framework. I aim to investigate the causal role of theta synchronisation between dynamic auditory and visual inputs on multisensory episode formation in the hippocampus, as it conveys the fundamental unit for speech perception. In a series of experiments, I will test the behavioural consequences of manipulating the theta phase synchrony between modalities, with a new memory task using natural speech episodes. I will combine this task with state-of-the-art electrophysiological recording techniques, i.e. Magneto-Encephalography (MEG), and single unit recording in the human hippocampus (intracranial Electro-Encephalography in epileptic patients). Lastly, I will implement the results in a recent theta-based speech model to test the effect of sensory input asynchrony on hippocampal networks.
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Grant Details
Amount Awarded | 250000 |
Applicant Surname | Biau |
Approval Committee | Basic Science Interview Committee |
Award Date | 2018-04-24T00:00:00+00:00 |
Financial Year | 2017/18 |
Grant Programme: Title | Sir Henry Wellcome Postdoctoral Fellowship |
Internal ID | 210924/Z/18/Z |
Lead Applicant | Dr Emmanuel Biau |
Partnership Value | 250000 |
Planned Dates: End Date | 2021-07-04T00:00:00+00:00 |
Planned Dates: Start Date | 2018-09-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | West Midlands |
Sponsor(s) | Prof Simon Hanslmayr |