Identification and characterization of novel peptides in snake venom that pharmacologically modulate the human P2X4 receptor
(360G-Wellcome-211430_Z_18_Z)
P2X receptors are ligand-gated ion channels activated by extracellular ATP. The human genome encodes seven receptors (P2X1-7) of which the P2X4 receptor has emerged as a promising drug target for the treatment of neuropathic pain and hypertension. However, progress in this area has been severely hampered by a paucity of selective small molecule modulators of P2X4. This project will seek to identify and characterise novel snake venom peptides that can pharmacologically manipulate the activity of the human P2X4 receptor.
Where is this data from?
This data was originally published by
The Wellcome Trust.
If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a
grantee amendment request.
You can hover over codes from
standard codelists
to see the user-friendly name provided by 360Giving.
360Giving uses privacy-respecting analytics. If you don't
accept cookies, we will track only basic information about your visit. Click "Disable Analytics" if you don't
want us to track at all.