Impact of varied reperfusion approaches following middle cerebral artery occlusion on the subsequent development of reperfusion injury (360G-Wellcome-211463_Z_18_Z)

Timely reperfusion of the occluded cerebral vasculature can minimize brain damage and optimize positive patient outcome. Current therapeutic approaches include administration of tissue plasminogen activator to dissolve an occlusive clot pharmacologically. More recently, mechanical clot removal devices are becoming a favoured approach. However, reperfusion injury can develop and haemorrhagic transformation (HT) of recently ischaemic brain is a potentially fatal complication of thrombolytic and mechanical reperfusion therapy. MMP-9 and MMP-2 expression in brain tissue is indicative of disruption of the blood brain barrier [3]. Heightened MMP-2 is associated with more favourable outcomes than MMP-9; high expression of MMP-9 is associated with haemorrhagic transformation and poorer clinical outcomes [4, 5]. Specific objectives during summer placement: - To experience real science by integrating into a research team. - To learn and master the techniques implicit in immunohistochemistry and other histological measures, including tissue slicing, antibody staining and quantitative assessment of biomarkers. - To contribute to the on-going assessment in the host lab, of the impact of varied reperfusion approaches following middle cerebral artery occlusion on the subsequent development of reperfusion injury. In particular, MMP-9 and MMP-2 expression in rat brain will be quantitatively assessed.

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Grant Details

Amount Awarded 0
Applicant Surname Neo
Approval Committee Internal Decision Panel
Award Date 2018-05-31T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Vacation Scholarships
Internal ID 211463/Z/18/Z
Lead Applicant Mr Wee Xuan Neo
Partnership Value 0
Planned Dates: End Date 2018-07-16T00:00:00+00:00
Planned Dates: Start Date 2018-05-17T00:00:00+00:00
Recipient Org: Country Ireland
Region Ireland