Mathematical modelling of inflammation (360G-Wellcome-211668_Z_18_Z)

£0

The proposed research seeks to build on existing mechanistic mathematical models for the inflammatory response by generalising them to structured-population frameworks able to capture, in particular, a continuum of macrophage states, motivated by a desire to shed light on the processes that regulate whether resolution or dysregulation of inflammation occurs. The level of the modelling assumptions and analysis will reflect what can realistically be achieved over the course of a Vacation Scholarship. Interactions of macrophages and neutrophils with bacterial biofilms will provide a concrete focus for the application of the general models, arising from discussions with (and enabling guidance from) microbiologists within the University. The key goals are: (i) Construction and extensive numerical simulation of a structured-population model that encompasses macrophage and neutrophil populations and builds directly on extant ordinary-differential-equation formulations. (ii) Generalisation of the model to include spatial effects, allowing the simulation of an idealised model for the interaction of inflammatory cells with a heterogeneous biofilm. (iii) Interpretation of results, providing the Scholar with experience of systems-biology research as applied to topics of direct relevance to healthcare.

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Grant Details

Amount Awarded 0
Applicant Surname de Vos
Approval Committee Internal Decision Panel
Award Date 2018-05-31T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Vacation Scholarships
Internal ID 211668/Z/18/Z
Lead Applicant Miss Kelly de Vos
Partnership Value 0
Planned Dates: End Date 2018-09-29T00:00:00+00:00
Planned Dates: Start Date 2018-07-30T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East Midlands