The effect of redox modulators on the LINC complex in metastatic breast cancer cells (360G-Wellcome-211669_Z_18_Z)

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The LINC complex is a nuclear membrane protein complex, which controls nuclear stiffness. This protein complex has been found to be deregulated in metastatic breast cancer cells, decreasing cell stiffness, and therefore increasing the cells’ ability to deform its nucleus and pass through pores and restricted spaces. This project aims to characterize the LINC complex of metastatic breast cancer cells, and to study the modifications that occur in its quaternary structure when cells are treated with drugs that alter their redox potential. Because this complex is stabilized by disulphide bonds, we propose that treatment of metastatic cells with drugs that modify the redox status of the cell and cause ER stress could have an effect on the LINC complex and restore its function. Thapsigargin is a natural endoplasmic reticulum (ER) stress inducer, and this increased ER stress will trigger apoptotic signalling pathways in the cell. Function restoration of the LINC complex would allow control over metastatic breast cancer cell migration, preventing the tumour from spreading and focalizing it in a specific area. The results obtained from this study may open up new treatment opportunities and the restriction of cell migration may improve the effectivity of current clinical treatments.

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Grant Details

Amount Awarded 0
Applicant Surname Ferraces Riegas
Approval Committee Internal Decision Panel
Award Date 2018-05-31T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Vacation Scholarships
Internal ID 211669/Z/18/Z
Lead Applicant Miss Paula Ferraces Riegas
Partnership Value 0
Planned Dates: End Date 2018-08-17T00:00:00+00:00
Planned Dates: Start Date 2018-06-18T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North East