Combinatorial pursuit to spinal cord injury rehabilitation using an Epac agonist and hydrogel, promoting axonal regeneration in an inhibitory environment. (360G-Wellcome-211678_Z_18_Z)

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Spinal cord injury imposes a daunting challenge on available regenerative procedures as its complexity lies in the considerable severity of symptoms, which are contingent on location and impact of injury to the spinal cord. Accordingly, it would require equally as drastic and diverse yet cohesive methods to combat such loss to motor and sensory physiological capabilities. Growth inhibition factors are activated after trauma below level of injury and the presence of the glial scar formation prevents any further axonal rejuvenation in the central nervous system. The aim of this research project is to systematically provide a supportive environment for axonal growth using a hydrogel scaffold biomaterial to circumvent the glial scar formation whilst simultaneously using an Epac (direct cAMP signaling effector) agonist to induce neuronal regeneration in the CNS inhibitory "hostile" environment. Using these two innovative methods reflects the difficulties in treating spinal cord injury, as using a singular strategy is ultimately insufficient to curing spinal cord injury all together.

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Grant Details

Amount Awarded 0
Applicant Surname Larossi
Approval Committee Internal Decision Panel
Award Date 2018-05-31T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Vacation Scholarships
Internal ID 211678/Z/18/Z
Lead Applicant Miss Niss Larossi
Partnership Value 0
Planned Dates: End Date 2018-09-01T00:00:00+00:00
Planned Dates: Start Date 2018-07-02T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland