Novel role of SXL in chromatin association (360G-Wellcome-211736_Z_18_Z)
Sex Lethal (Sxl) is a gene which acts as a gender-switch in flies. In females, a full-length form of Sxl (SxlF) is present which initiates the start of female-specific development. In males however, a shorter form of Sxl (SxlM) is made which is unable to fulfil this function. Recently however, much research has highlighted the potential importance of similarly short proteins, termed micropeptides, in regulating pathways and protein function. As previous research has escaped SxlM due to its tiny size, it’s possible that SxlM fulfils some important role within male development which has yet to be determined. This project will investigate the importance of SxlM in the development of male physiology and behaviour, and attempt to understand how it may fulfil these roles through a novel molecular profiling technique termed Targeted DamiD, TaDa.
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