Role of interleukin 22 receptor expression in Human Respiratory Syncytial Virus infection. Positive or negative? (360G-Wellcome-211882_Z_18_Z)

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Respiratory Syncytial Virus (RSV) is the commonest cause of severe respiratory tract infection in infants with a global RSV disease burden of around 30 million cases each year. The cytokine IL-22 is known to be expressed at sites of infection, to enhance cell growth, tissue repair and aid protection from secondary infection by increasing secretion of antibacterial molecules including beta defensin. A previous student led project has shown RSV infection of cultured airway epithelial cells results in increased expression of the receptor IL-22R1 polypeptide. Potentially increasing the sensitivity of these cells to stimulation by IL-22. Here we wish to establish if IL-22 treatment of cultured airway epithelia cells has a positive effect through increasing beta defensin expression and or a negative effect increasing infected cell viability and RSV replication. This will be achieved by infecting beas-2B airway epithelial cells in vitro and studying IL-22R1 expression, viral replication and beta- defensin expression. This will work will provide a further understanding of IL-22 role during viral infection and potentially define if IL-22R or IL-22 are possible therapeutic targets.

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Grant Details

Amount Awarded 0
Applicant Surname Jones Evans
Approval Committee Internal Decision Panel
Award Date 2018-05-31T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Vacation Scholarships
Internal ID 211882/Z/18/Z
Lead Applicant Miss Marian Jones Evans
Partnership Value 0
Planned Dates: End Date 2018-08-03T00:00:00+00:00
Planned Dates: Start Date 2018-06-04T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West