Microneedle delivery of the anti-psychotic medicine haloperidol decanoate (360G-Wellcome-211905_Z_18_Z)

This project involves development of a novel dissolving microneedle array device, incorporating a nano suspension of haloperidol decanoate to provide transdermal delivery of a formulation that will dissolve in skin and act as a depot. Dissolving microneedle arrays are minimally invasive devices, consisting of an array of micro projections arranged on a baseplate in a defined configuration. These microneedles, up to 600 µm in length, are hard in the dry state and when applied to the skin using manual thumb pressure, painlessly penetrate the outermost layer of the skin, the stratum corneum. The needle tips dissolve in interstitial fluid releasing the nano suspension formulation into the viable skin tissue. Haloperidol can then be slowly and constantly be release over long periods of time to maintain constant plasma levels. A number of key parameters need to be assessed: 1. Nanosuspension formulation using a nano precipitate/ultra sonification method 2. Nanosuspension physicochemical characterisation for particle size and zeta potential 3. Formulation of microneedle arrays using aqueous blends of biocompatible polymers 4. In skin dissolution of the microneedle formulations

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Grant Details

Amount Awarded 0
Applicant Surname McSorley
Approval Committee Internal Decision Panel
Award Date 2018-05-31T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Vacation Scholarships
Internal ID 211905/Z/18/Z
Lead Applicant Miss Danielle McSorley
Partnership Value 0
Planned Dates: End Date 2018-09-01T00:00:00+00:00
Planned Dates: Start Date 2018-07-02T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Northern Ireland