Oestrogens and beta adrenoceptors in the heart (360G-Wellcome-211969_Z_18_Z)
The actions of oestrogen on the heart are poorly understood. The preliminary findings of the lab group (Prof K MacLeod) I am hoping to join suggest long-term absence of ovarian hormones lead to potentially detrimental changes in Ca2+ handling mechanisms in the heart that may cause the formation of a more pro-arrhythmic substrate. Oestradiol replacement prevented these adverse effects. The work I hope to be involved in will investigate if lack of oestrogens alters Ca2+ regulation by changing the number or function of beta adrenoceptors (beta-ARs) thus altering the efficacy of cardiac excitation contraction coupling and cellular Ca2+ regulation.
Where is this data from?
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Grant Details
| Amount Awarded |
0
|
| Applicant Surname | Arjomandi Rad |
| Approval Committee | Internal Decision Panel |
| Award Date | 2018-05-31T00:00:00+00:00 |
| Financial Year | 2017/18 |
| Grant Programme: Title | Vacation Scholarships |
| Internal ID | 211969/Z/18/Z |
| Lead Applicant | Mr Arian Arjomandi Rad |
| Partnership Value | 0 |
| Planned Dates: End Date | 2018-09-21T00:00:00+00:00 |
| Planned Dates: Start Date | 2018-07-22T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |