A modern cryo-EM facility at Imperial College London (360G-Wellcome-212938_Z_18_Z)
Cryo-electron microscopy (cryoEM) is becoming the major tool in elucidating the inner workings of cellular machines. In 1997, Imperial College London, with help from the Wellcome Trust, established the first cryoEM facility dedicated to single particle work in the UK and, through the continuing support of WT, has been an international leading player and centre of excellence in cryoEM. Our current user community has benefited tremendously from this excellent facility. However, equipment in the facility, especially for grid preparation and handling, is in urgent need of upgrading or refurbishment, and is insufficient in capacity. With the successful award of a Titan Krios from the WT (LonCEM) and access to national resources (eBIC), the focus of our facility is shifting from data collection to sample preparation, screening and preliminary data generation. We therefore request funds to upgrade our facilities in terms of grid preparation and screening to maintain competitiveness and embrace new technology development. The proposed upgrades will transform the throughput and quality of our sample preparation providing a state of the art capability allowing us to make optimal use of the LonCEM Krios facility when that comes online (late 2018) as well as other national (eBIC) and international resources.
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Grant Details
Amount Awarded | 197672 |
Applicant Surname | Meier |
Approval Committee | Multi-User Equipment and Technology Development Committee |
Award Date | 2018-07-05T00:00:00+00:00 |
Financial Year | 2017/18 |
Grant Programme: Title | Multi-User Equipment Grant |
Internal ID | 212938/Z/18/Z |
Lead Applicant | Prof Thomas Meier |
Other Applicant(s) | Dr Christopher Aylett, Dr Doryen Bubeck, Dr Morgan Beeby, Prof Christian Speck, Prof Dale Wigley, Prof Erhard Hohenester, Prof Jake Baum, Prof Paul Freemont, Prof Xiaodong Zhang |
Partnership Value | 197672 |
Planned Dates: End Date | 2023-08-01T00:00:00+00:00 |
Planned Dates: Start Date | 2018-08-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |