Foundations for routine 3D X-ray histology (360G-Wellcome-212940_Z_18_Z)

£1,135,071

Whilst 3D medical imaging is commonplace, microscopic tissue structure analysis (i.e. histology) remains overwhelmingly wedded to ~200-year-old practices of microscopic 2D examination of tissue sections. Building on our first demonstrated assessment of 3D microstructural detail in standard wax-embedded soft tissue (Scott et al., 2015, http://dx.doi.org/10.1371/journal.pone.0126230) we will develop the foundations for routine 3D X-ray histology by: Providing: Robust, non-destructive, high-throughput 3D microscopic imaging of routinely processed soft tissue samples at 5-10 µm resolution. Access to orders of magnitude more tissue structure data per sample (cf. optical sections). Tissue-level volumetric structure and connectivity insights (previously unavailable). Correlative 3D data supplementing other routine or specialist imaging (e.g. immunostaining, laser microdissection). Routes to novel medical and scientific discovery (Jones et al., 2016, http://dx.doi.org/10.1172/jci.insight.86375; Koo et al., 2018, in revision). Establishing: Hardware approaches to increased sample throughput. Standardised, automated workflows for image acquisition, calibration, CT reconstruction, data handling. Long-term roadmap for emerging X-ray technology improvements targeted for biomedical applications. Raising awareness/driving uptake through: Pilot studies (n~10 samples/study)/new applications validated by 2D histology and integrated with correlative imaging modalities. Biomedical case studies (n~100) at high statistical power. Data resources (n~100) for artificial intelligence and deep learning approaches in digital 3D histopathology.

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Grant Details

Amount Awarded 1135071
Applicant Surname Schneider
Approval Committee Biomedical Resource Committee
Award Date 2018-07-05T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Technology Development Grant
Internal ID 212940/Z/18/Z
Lead Applicant Prof Philipp Schneider
Other Applicant(s) Dr Anton Page, Dr J Arjuna Ratnayaka, Prof Gareth Thomas, Prof Ian Sinclair, Prof Simon Cox
Partnership Value 1135071
Planned Dates: End Date 2023-06-16T00:00:00+00:00
Planned Dates: Start Date 2019-01-16T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East