State-of-the-art proteomics for Newcastle University (360G-Wellcome-212947_Z_18_Z)

Proteomics is a powerful tool that is increasingly used by scientists in a wide range of biologically and medically important areas. Here, we are requesting funds for a cutting-edge liquid-chromatography mass spectrometry (LC-MS) system that will enable us to support Wellcome-funded researchers in Newcastle with access to state-of-the-art proteomics. We will utilise this instrument to enhance the research of a number of exceptionally successful clinically relevant research groups. In particular, we will perform quantitative proteomics to identify changes to the mitochondrial proteome in response to disease mutations, characterise immune populations during early human development, the role of mutations in inflammatory disease in humans, analyse molecular pathways and identify biomarkers in liver disease and fibrosis, and describe molecular mechanisms in bacterial cell biology and pathogenicity. Overall, this instrumentation will boost the research of Wellcome-funded researchers at Newcastle University.