Fuelling pathogenicity: nutrient adaptation of human fungal pathogens (360G-Wellcome-214317_Z_18_Z)
During infection, mammalian hosts restrict the availability of key micronutrients in a process called "nutritional immunity". To cause disease, pathogens have evolved ways to circumvent this restriction. Building on discoveries made in my Sir Henry Dale Fellowship, this proposal addresses three key aspects of Candida albicans nutrient adaptation during colonisation and infection. I will define the signalling pathways orchestrating intracellular nutrient trafficking. Eukaryotic pathogens have the unique capacity to store high levels of micronutrients. I have shown that this fuels virulence and will now dissect the molecular mechanisms and regulatory pathways governing this important process. I will determine the mechanistic basis of competition for zinc at the host-pathogen interface. Having discovered the first zincophore zinc scavenging system of any pathogen, I will now structurally resolve this crucial micronutrient assimilation protein and show how it allows fungi to secure this essential micronutrient during infection. I will show how C. albicans Goliath cells, a novel morphotype I recently discovered, pioneer the colonisation of the mammalian gut. Here I will take advantage of this seminal discovery to understand how C. albicans establishes it commensal niche.
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Grant Details
Amount Awarded | 1712381 |
Applicant Surname | Wilson |
Approval Committee | Science Interview Panel |
Award Date | 2018-11-27T00:00:00+00:00 |
Financial Year | 2018/19 |
Grant Programme: Title | Senior Research Fellowship |
Internal ID | 214317/Z/18/Z |
Lead Applicant | Dr Duncan Wilson |
Partnership Value | 1712381 |
Planned Dates: End Date | 2019-08-31T00:00:00+00:00 |
Planned Dates: Start Date | 2019-05-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Scotland |