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Cholera vaccine effectiveness in Nsanje and Chikwawa, Malawi (360G-Wellcome-214662_Z_18_Z)

<p style="margin-left: 0cm; margin-right: 0cm">Following the 2015 oral cholera vaccine (OCV) mass campaign of 160,000 people in Nsanje District, Malawi, the International Vaccine Institute (IVI) was funded to setup diarrheal disease surveillance in Nsanje and adjacent Chikwawa districts. Surveillance is ongoing at&nbsp;<u>22 and 18 health care facilities</u>in Nsanje and Chikwawa, respectively. Research activities include to 1) analyse the vaccine effectiveness (VE) in Nsanje, through a 1:4 case-control study and 2) conduct a cost-of-illness study to help estimate OCV cost-effectiveness.&nbsp;</p> <p style="margin-left: 0cm; margin-right: 0cm">The IVI is working in parallel in neighboring Mozambique. Diarrheal disease surveillance is ongoing in the Cuamba study area and an OCV has been conducted in 08/2018. The Mozambique study area borders the Malawian Nsanje/Chikwawa districts.</p> <p style="margin-left: 0cm; margin-right: 0cm">We propose to continue the research in Malawi through extending the surveillance work and the case-control study, to ensure the assessment of long-term VE and cost-effectiveness. Further, the extent of herd protection through OCV needs to be assessed; the Chikwawa setting, after the 2018 OCV campaign constitutes the perfect scenario.</p> <p style="margin-left: 0cm; margin-right: 0cm">The GFTCC is currently preparing a research agenda for &ldquo;End cholera by 2030&rdquo; roadmap and the Malawi/Mozambique scenario with surveillance ongoing in both countries, provides an unique opportunity to answer research questions identified through the GFTCC.&nbsp;&nbsp;&nbsp;</p>

£311,974

30 Sep 2018

Grant details
Amount Awarded 311974
Applicant Surname Marks
Approval Committee Internal Decision Panel
Award Date 2018-09-30T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title DFID-Wellcome Epidemic Preparedness Grant
Internal ID 214662/Z/18/Z
Lead Applicant Dr Florian Marks
Planned Dates: End Date 2020-06-30T00:00:00+00:00
Planned Dates: Start Date 2018-09-30T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Additional data added by GrantNav