Fibrin films at the crossroads of haemostasis, infection control and wound healing (360G-Wellcome-215861_Z_19_Z)

£300,000

We have recently shown that fibrin forms a continuous film covering the air-blood interface of external wounds, and that these film form an almost instantaneous barrier protecting the wound against infection for at least 12 hours. This discovery is potentially paradigm-shifting in haemostasis presenting a new area of research with novel translational opportunities. I propose that fibrin films help prevent wound infection for 24-48 hours by providing a barrier across the surface of an external wound. In turn, this preclusion of infection aids the wound healing process by preventing prolonged inflammation at the site of injury. To investigate this I will assess the role of the film in preventing the proliferation and dissemination of bacteria in murine models of dermal infection over 72 hours, and explore if fibrin films can prevent infection from becoming blood-borne. I will go on to investigate how this prevention of infection influences wound healing using a murine wound healing model, and study how fibrin films influence white blood cell and fibroblast infiltration. These lines of investigation will bring together the fields of haemostasis, infection and tissue repair, uncovering new pathways to target in the treatment of dermal and blood borne infections and wound healing.

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Grant Details

Amount Awarded 300000
Applicant Surname Macrae
Approval Committee Basic Science Interview Committee
Award Date 2019-04-24T00:00:00+00:00
Financial Year 2018/19
Grant Programme: Title Sir Henry Wellcome Postdoctoral Fellowship
Internal ID 215861/Z/19/Z
Lead Applicant Mr Fraser Macrae
Partnership Value 300000
Planned Dates: End Date 2024-09-30T00:00:00+00:00
Planned Dates: Start Date 2019-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Yorkshire and the Humber
Sponsor(s) Prof Robert Ariëns