Fibrin films at the crossroads of haemostasis, infection control and wound healing (360G-Wellcome-215861_Z_19_Z)
We have recently shown that fibrin forms a continuous film covering the air-blood interface of external wounds, and that these film form an almost instantaneous barrier protecting the wound against infection for at least 12 hours. This discovery is potentially paradigm-shifting in haemostasis presenting a new area of research with novel translational opportunities. I propose that fibrin films help prevent wound infection for 24-48 hours by providing a barrier across the surface of an external wound. In turn, this preclusion of infection aids the wound healing process by preventing prolonged inflammation at the site of injury. To investigate this I will assess the role of the film in preventing the proliferation and dissemination of bacteria in murine models of dermal infection over 72 hours, and explore if fibrin films can prevent infection from becoming blood-borne. I will go on to investigate how this prevention of infection influences wound healing using a murine wound healing model, and study how fibrin films influence white blood cell and fibroblast infiltration. These lines of investigation will bring together the fields of haemostasis, infection and tissue repair, uncovering new pathways to target in the treatment of dermal and blood borne infections and wound healing.
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Grant Details
Amount Awarded | 300000 |
Applicant Surname | Macrae |
Approval Committee | Basic Science Interview Committee |
Award Date | 2019-04-24T00:00:00+00:00 |
Financial Year | 2018/19 |
Grant Programme: Title | Sir Henry Wellcome Postdoctoral Fellowship |
Internal ID | 215861/Z/19/Z |
Lead Applicant | Mr Fraser Macrae |
Partnership Value | 300000 |
Planned Dates: End Date | 2024-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2019-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Yorkshire and the Humber |
Sponsor(s) | Prof Robert Ariëns |