Emergence and global epidemiology of non-polio enteroviruses (360G-Wellcome-216427_Z_19_Z)

£909,233

I aim to identify the mechanisms driving the emergence of enterovirus serotypes as a new cause of disease and their spatio-temporal patterns of spread using multiple data streams and mathematical and statistical models. First, I will study the extent to which serotype-specific immunity explains the cyclical incidence of enteroviruses causing hand-foot-and-mouth disease, both by fitting transmission models to incidence data and exploring correlations with estimates of population immunity from serosurveys. Second, using cross-sectional seroprevalence and virus sequence data I will explore how gaps in population immunity and virus genotypic and phenotypic changes have led to the recent emergence of two new serotypes causing diseases (EV-D68 and CV-A6) following periods of low incidence of cases. Third, using phylogenetic and phylogeographic methods, I will characterise the geographical range of spread and global and regional patterns of viral movement of the three currently most important serotypes (EV-A71, EV-D68 and CV-A6), and I will explore how human mobility and other predictors drive these spatial patterns. Understanding the mechanisms underlying the epidemiological dynamics of enteroviruses will help prioritise strategies to mitigate the morbidity associated to these infections by informing the serotypes that should be targeted by future vaccines, and optimise outbreak control and vaccination strategies.

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Grant Details

Amount Awarded 909233
Applicant Surname Pons Salort
Approval Committee Sir Henry Dale Fellowship Interview Committee
Award Date 2019-06-12T00:00:00+00:00
Financial Year 2018/19
Grant Programme: Title Sir Henry Dale Fellowship
Internal ID 216427/Z/19/Z
Lead Applicant Dr Margarita Pons Salort
Partnership Name Royal Society/Wellcome Trust Sir Henry Dale Fellowship
Partnership Value 909233
Planned Dates: End Date 2025-12-31T00:00:00+00:00
Planned Dates: Start Date 2020-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Neil Ferguson