Emergence and global epidemiology of non-polio enteroviruses (360G-Wellcome-216427_Z_19_Z)
I aim to identify the mechanisms driving the emergence of enterovirus serotypes as a new cause of disease and their spatio-temporal patterns of spread using multiple data streams and mathematical and statistical models. First, I will study the extent to which serotype-specific immunity explains the cyclical incidence of enteroviruses causing hand-foot-and-mouth disease, both by fitting transmission models to incidence data and exploring correlations with estimates of population immunity from serosurveys. Second, using cross-sectional seroprevalence and virus sequence data I will explore how gaps in population immunity and virus genotypic and phenotypic changes have led to the recent emergence of two new serotypes causing diseases (EV-D68 and CV-A6) following periods of low incidence of cases. Third, using phylogenetic and phylogeographic methods, I will characterise the geographical range of spread and global and regional patterns of viral movement of the three currently most important serotypes (EV-A71, EV-D68 and CV-A6), and I will explore how human mobility and other predictors drive these spatial patterns. Understanding the mechanisms underlying the epidemiological dynamics of enteroviruses will help prioritise strategies to mitigate the morbidity associated to these infections by informing the serotypes that should be targeted by future vaccines, and optimise outbreak control and vaccination strategies.
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Grant Details
Amount Awarded | 909233 |
Applicant Surname | Pons Salort |
Approval Committee | Sir Henry Dale Fellowship Interview Committee |
Award Date | 2019-06-12T00:00:00+00:00 |
Financial Year | 2018/19 |
Grant Programme: Title | Sir Henry Dale Fellowship |
Internal ID | 216427/Z/19/Z |
Lead Applicant | Dr Margarita Pons Salort |
Partnership Name | Royal Society/Wellcome Trust Sir Henry Dale Fellowship |
Partnership Value | 909233 |
Planned Dates: End Date | 2025-12-31T00:00:00+00:00 |
Planned Dates: Start Date | 2020-01-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Neil Ferguson |