Enabling imaging of cells and tissues across scales (360G-Wellcome-218278_Z_19_Z)
We seek funding for an array tomography scanning electron microscope (SEM) with ATLAS 5 software together with components to upgrade an associated light microscope, to enable 3D correlative light and electron microscopy (CLEM) of cells and tissues with nm resolution. Array tomography SEM allows for the detection, mapping and automated imaging of serial sections of resin embedded samples and is non-destructive technology. This technology is transformative and will enable high resolution 3D correlation of molecular machineries with cellular structure and specific cell and tissue processes. Using this new technology, our initial consortium of PIs will address the following specific objectives: 1. To elucidate the mechanism of 3D patterning during organogenesis (Pichaud) 2. To characterise the fundamental principle that regulate intracellular trafficking of cargoes and membrane, storage and lysosomal degradation (Brodsky, Futter and Schiavo) 3. To determine the molecular basis for the interaction between the HIV virus and its host cells and tissues (Jolly and Marsh) 4. To elucidate the fundamental mechanisms of nuclear remodelling during passage through mitosis (Baum) 5. To elucidate the connectivity underlying circuit function (Hausser and Wilson) Altogether, our proposed studies will elucidate fundamental mechanisms of cell and tissue morphogenesis, homeostasis, function repair and infection.
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Grant Details
Amount Awarded | 333750 |
Applicant Surname | Pichaud |
Approval Committee | Multi-User Equipment and Technology Development Committee |
Award Date | 2019-07-04T00:00:00+00:00 |
Financial Year | 2018/19 |
Grant Programme: Title | Multi-User Equipment Grant |
Internal ID | 218278/Z/19/Z |
Lead Applicant | Prof Franck Pichaud |
Other Applicant(s) | Dr Buzz Baum, Dr Jemima Burden, Prof Clare Futter, Prof Clare Jolly, Prof Frances Brodsky, Prof Giampietro Schiavo, Prof Mark Marsh, Prof Michael Hausser, Prof Stephen Wilson |
Partnership Value | 333750 |
Planned Dates: End Date | 2024-09-01T00:00:00+00:00 |
Planned Dates: Start Date | 2019-09-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |