Carbohydrate Microarray Facility for the New Era of Glycomics (360G-Wellcome-218304_Z_19_Z)

£1,340,042

The Carbohydrate Microarray Facility at Imperial is an internationally leading operation providing collaborations for discoveries of glycan ligands to the biomedical community (http://www.imperial.ac.uk/glycosciences/). Data accrued are making significant contributions to understanding the involvement of specific glycans in health, infections, inflammation, immune responses and cancer. This unique collaborative way of serving the community, with follow-through of data from screening analyses, has enabled substantial advances to be made in glycobiology. Access to ample amounts of glycans that is often required to corroborate assignments from screening analyses has largely depended so far on external collaborations with chemists. New links that we are forging with the Department of Chemistry to provide desired glycans are of fundamental value for the future of the Facility. We are seeking 4 years support to further integrate the new era of glycomics into biology and medicine. We will develop a unique human epithelial mucin/O-glycome resource for diverse recognition studies, in particular microbe-host interactions. expand the ‘glycosaminoglycome’ and brain ‘gangliome’ library. complement and diversify the library of glycan sequences with chemically and chemo-enzymatically synthesized glycans, guided from glycan array data. introduce new software for integrated data management and data mining of glycome array analyses.

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Grant Details

Amount Awarded 1340042
Applicant Surname Liu
Approval Committee Biomedical Resource Committee
Award Date 2019-07-04T00:00:00+00:00
Financial Year 2018/19
Grant Programme: Title Biomedical Resources Grant
Internal ID 218304/Z/19/Z
Lead Applicant Dr Yan Liu
Other Applicant(s) Dr Benjamin Schumann, Dr Wengang Chai, Prof Phillip Bennett, Prof Ten Feizi
Partnership Value 1340042
Planned Dates: End Date 2024-09-30T00:00:00+00:00
Planned Dates: Start Date 2019-11-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London