Investigating the molecular basis of cellular diversity in the nervous system (360G-Wellcome-218536_Z_19_Z)

£1,395,934

Neural induction is the process responsible for the generation of the entire nervous system. A major question in the field is how this process results in the production of diverse cell types throughout the nervous system, and how it can be applied to regenerative medicine. I recently showed that CDX transcription factors are critical to establish spinal cord fate, but that their capacity to induce spinal cord is lost following neural lineage commitment. Moreover, my preliminary data suggests that CDX factors broadly impact posterior identity in cells, prior to germ layer segregation, that is critical for the generation of different neural subtypes in the nervous system in vivo. In this proposal, the key goals are to: investigate the regulatory mechanisms limiting Cdx2 expression in cells; evaluate how CDX2 represses alternative brainstem fates for the generation of spinal cord; and test the role of CDX in the divergence of neural cells, including neural crest cells, that form distinct fates within the nervous system, in vivo. Taken together, this work will provide molecular insight into how cellular diversity is established in the mammalian nervous system and more generally throughout the body plan.

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Grant Details

Amount Awarded 1395934
Applicant Surname Metzis
Approval Committee Sir Henry Dale Fellowship Interview Committee
Award Date 2019-10-16T00:00:00+00:00
Financial Year 2019/20
Grant Programme: Title Sir Henry Dale Fellowship
Internal ID 218536/Z/19/Z
Lead Applicant Dr Vicki Metzis
Partnership Name Royal Society/Wellcome Trust Sir Henry Dale Fellowship
Partnership Value 1360539
Planned Dates: End Date 2025-03-09T00:00:00+00:00
Planned Dates: Start Date 2020-03-09T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Dame Amanda Fisher