Identifying the genetic determinants of Fusobacterium associated with diarrhoeal disease and colorectal cancer in Vietnam (360G-Wellcome-218726_Z_19_Z)
The gut microbiome and its dysbiosis play a central role in understanding infectious and non-infectious conditions. Evidence suggests Fusobacterium nucleatum, an oral anaerobic bacterial pathobiont, potentiates colonic tumourigenesis. My recent work in Vietnam indicates that Fusobacterium, including F. nucleatum, is also enriched in the gut microbiome of children during infectious diarrhoea. My aim is to define the role of Fusobacterium in the resolution of infectious diarrhoea and the development of colorectal cancer, through integrating 16S rRNA-based metagenomics in two distinct clinical studies in Vietnam. I will examine the impact of Fusobacterium gastrointestinal overgrowth and microbiome dysbiosis on diarrhoeal duration in children. Additionally, I will measure the prevalence and distribution of F. nucleatum in the microbiomes of gut mucosa taken from colorectal cancer patients. I will perform whole genome sequencing on the F. nucleatum isolated from collected saliva, diarrhoea stools, and colonic tumour mucosa. Using genomics and phylogenetic analyses, I aim to identify genetic factors associated with F. nucleatum colonization in different human body compartments (oral, colonic) and pathological states (tumour, non-tumour). These findings will enable future in-depth studies, contributing to the development of non-invasive diagnostic marker for colorectal cancer and targeted Fusobacterium therapies in these two diseases.
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Grant Details
Amount Awarded | 223772 |
Applicant Surname | Chung |
Approval Committee | International Interview Committee |
Award Date | 2019-11-19T00:00:00+00:00 |
Financial Year | 2019/20 |
Grant Programme: Title | International Training Fellowship |
Internal ID | 218726/Z/19/Z |
Lead Applicant | Dr Hao Chung |
Partnership Value | 223772 |
Planned Dates: End Date | 2024-05-31T00:00:00+00:00 |
Planned Dates: Start Date | 2020-06-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |
Sponsor(s) | Prof Guy Thwaites |