Identifying the genetic determinants of Fusobacterium associated with diarrhoeal disease and colorectal cancer in Vietnam (360G-Wellcome-218726_Z_19_Z)

£223,772

The gut microbiome and its dysbiosis play a central role in understanding infectious and non-infectious conditions. Evidence suggests Fusobacterium nucleatum, an oral anaerobic bacterial pathobiont, potentiates colonic tumourigenesis. My recent work in Vietnam indicates that Fusobacterium, including F. nucleatum, is also enriched in the gut microbiome of children during infectious diarrhoea. My aim is to define the role of Fusobacterium in the resolution of infectious diarrhoea and the development of colorectal cancer, through integrating 16S rRNA-based metagenomics in two distinct clinical studies in Vietnam. I will examine the impact of Fusobacterium gastrointestinal overgrowth and microbiome dysbiosis on diarrhoeal duration in children. Additionally, I will measure the prevalence and distribution of F. nucleatum in the microbiomes of gut mucosa taken from colorectal cancer patients. I will perform whole genome sequencing on the F. nucleatum isolated from collected saliva, diarrhoea stools, and colonic tumour mucosa. Using genomics and phylogenetic analyses, I aim to identify genetic factors associated with F. nucleatum colonization in different human body compartments (oral, colonic) and pathological states (tumour, non-tumour). These findings will enable future in-depth studies, contributing to the development of non-invasive diagnostic marker for colorectal cancer and targeted Fusobacterium therapies in these two diseases.

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Grant Details

Amount Awarded 223772
Applicant Surname Chung
Approval Committee International Interview Committee
Award Date 2019-11-19T00:00:00+00:00
Financial Year 2019/20
Grant Programme: Title International Training Fellowship
Internal ID 218726/Z/19/Z
Lead Applicant Dr Hao Chung
Partnership Value 223772
Planned Dates: End Date 2024-05-31T00:00:00+00:00
Planned Dates: Start Date 2020-06-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof Guy Thwaites