- Total grants
- Total funders
- Total recipients
- Earliest award date
- 09 Jun 1998
- Latest award date
- 29 May 2020
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
The Time Travelling Operating Theatre. 14 Jan 2015
In the past three years Imperial's Department of Surgery has run a series of highly successful, Wellcome-funded events using surgical simulation. The objective of these events has been to simulate current day operating theatres as a way of opening the closed world of surgery to the public. Alongside this the department has run another Wellcome-funded project recapturing the history of twentieth-century surgery through simulation-based re-enactment. Through this project, pioneering work has been undertaken investigating the roots of 'minimally invasive' surgery, a practice now considered standard. Our project takes these ideas a creative step forward by constructing a transportable simulation, which will show three different eras of surgery - 1884, 1984 and 2014 - during one viewing (a sequential simulation). Each two-hour event will comprise a comparable re-enactment of surgery from each of these three dates, performed by medical professionals from our wide range of contacts. In -between each performance there will be an opportunity for discussion between the audience, the performers and a small panel of experts, including historians, ethicists and medical professionals. Thus, the events will be fully participatory, with audience members invited not just to listen and witness but also to engage and contribute. By stimulating discussion about what surgery has been and what it might become, this project will contribute to public understanding of the history of surgery. It will also invite new perspectives on expectations upon future surgery, which will feed into wider ethical discussions and policy-making.
The Heart & Lung Repair Shops Extension 31 Mar 2015
The Heart and Lung Convenience Store will be the National Heart and Lung Institute's second popup science shop, embedding creative science engagement within the community setting of a bustling West London shopping centre. Academics, clinicians and researchers will collaborate with artists, designers, craftspeople and performers to transform an empty retail unit in Hammersmith's Kings Mall into a visually captivating space. The visitor experience will incorporate interactive multi-sensory activities engaging audiences with topics including personalised medicine, rapid diagnosis, targeted treatments, healthcare technologies and generally more convenient heart and lung healthcare for the future. The shop will open for two weeks from 19 October-1 November 2015. Audiences will engage through visual exhibits and displays, participatory installations, demonstrations, workshops, talks and performances. In addition to standard opening hours we will hold special events both within the shop and at local community venues including evening debates, schools workshops, a heart and lung comedy night, a heart and lung pub quiz and a heart and lung hackathon. The project will have an online presence through the NHLI website, The Heart and Lung Convenience Store Shopping Channel on YouTube where filmed content will be collected, partner organisation websites (including Fun Kids radio) and social media channels.
Respiratory syncytial virus infection in the elderly: Understanding the effects of aging on the innate immune response 02 Feb 2015
Respiratory infections, such as Respiratory Syncytial Virus (RSV) are a leading cause of morbidity and mortality worldwide, especially among the growing elderly population. Yet the impact of age-related changes in immunity in the lung remains insufficiently studied. In this project, we aim to establish an elderly murine model of RSV infection to studyhow aging alters anti-viral innate immune responses. Old (19-21 months) and young (2-3 months) C57BL/6 mice will be intranasally infected with the human RSV strain A2, and differences ininnate and adaptive immune responses characterised. We hypothesise that there are intrinsic differences in elderly alveolar macrophages, which determine how they respond to RSV and the outcome of infection, and we aim to identify key pathways that are altered in these cellswith age. Using this knowledge, we aim to manipulate the immune response in the elderly to reduce RSV-induced pathology. Finally, through collaboration with clinical colleagues, we will determine whether key mechanisms identified in the elderly mouse model, also differ in human infection in the elderly. Such studies will reveal novel insights into how the immune response to respiratory infection is altered in the elderly, aiding in the future development of new treatments andvaccines.
Modulation of MER tyrosine kinase signalling in liver failure: A therapeutic strategy to reverse immuneparesis and susceptibility to infection. 26 Feb 2015
Sepsis is a major cause of mortality for patients suffering from acute-on-chronic liver failure (ACLF). My preliminary data demonstrates a pivotal role for MERTK signalling in suppression of monocytes/macrophages immune responses to microbial challenge, increasing susceptibility to infections. Objectives: We will test the hypothesis that MERTK positive monocytes/macrophages are functionally hyporesponsive to microbial challenge, resulting in infection susceptibility across compartments, with e xploration of the autocrine and paracrine mechanisms suggested in our preliminary data. We will study the factors that influence MERTK expression as monocytes migrate across endothelia. Finally, we will investigate the potential for timely MERTK inhibition to reverse immune defects. Methods: Monocytes/macrophages from circulation, liver, lymph nodes and peritoneum from patients with ACLF and comparator groups will be isolated, and analysed using FACS-based techniques. Transendothelial migration will be assessed using cell migration models. Downstream effects of MERTK-agonists/antagonists on the MERTK signalling pathway will be evaluated in vitro. Using this data, we will evaluate the efficacy of inhibiting MERTK signalling as a strategy to restore ex-vivo monocyte function in ACLF patients, providing proof-of principle data for development of this as a novel therapeutic strategy to reverse immuneparesis, reducing susceptibility to infection and improve the outcome of this devastating condition.
Patients with advanced Chronic Obstructive Pulmonary Disease (COPD) have significant morbidity, poor quality of life and high mortality. As such, they are likely to be well served by a palliative care approach, but many fail to access palliative care services. One reason for this is that COPD commonly has an unpredictable disease trajectory, making identification of those in the last year of life difficult. This study will create a prognostic tool to help identify patients with COPD in the l ast year of life through use of electronic health records (GP records linked to hospital records). We will use this model to identify patients with advanced COPD and explore their experiences through interviews. We will use qualitative methodology to identify barriers and facilitators to accessing palliative care both from the perspective of patients and health care professionals. Drawing these streams together with further stakeholder input we will produce recommendations on how services should be redesigned to better meet the needs of patients with advanced COPD.